The UN Security Council has unanimously adopted a binding resolution on ridding Syria of chemical weapons.
At a session in New York, the 15-member body backed the draft document agreed earlier by Russia and the US.
The deal breaks a two-and-a-half year deadlock in the UN over Syria, where fighting between government forces and rebels rages on.
The vote came after the international chemical watchdog agreed on a plan to destroy Syria’s stockpile by mid-2014.
Speaking after the vote in New York, UN Secretary General Ban Ki-moon described the decision as “historic”.
“Tonight the international community has delivered.”
He urged the Syrian government to implement the resolution “faithfully and without delay”, and also announced a tentative date of mid-November for a new peace conference in Geneva.
US Secretary of State John Kerry said the UN demonstrated that “diplomacy can be so powerful that it can peacefully defuse the worst weapons of war”.
He said the resolution would for the first time seek to eliminate entirely a nation’s chemical weapons capability.
Russian Foreign Minister Sergei Lavrov also hailed the move, saying Moscow “was ready to take part in all operations” in Syria.
However, he stressed that the success of international efforts was “not only on Damascus’ shoulders” and that Syrian opposition must co-operate.
The UN resolution condemns the use of chemical weapons but does not attribute blame.
The text has two legally binding demands: that Syria abandon its weapons stockpile and that the chemical weapons experts be given unfettered access.
Although the draft refers to Chapter VII of the UN Charter, which allows the use of military force, a second resolution authorising such a move would be needed.
US President Barack Obama earlier said agreement on the issue by council members would be a “potentially huge victory for the international community”.
Previous attempts at a resolution stumbled amid disagreements between Russia and the US on how to deal with the crisis in Syria.
The US – backed by France and the UK – had pushed for a resolution carrying the threat of military action against Syrian President Bashar al-Assad’s armed forces. Russia had opposed this.
Reacting to the vote, Syria’s UN Ambassador Bashar Jaafari said the resolution covered most of Damascus’ concerns.
But he stressed that countries supporting Syrian rebels should also abide by the adopted document.
The UN vote came just hours after the Organisation for the Prohibition of Chemical Weapons (OPCW) adopted what it called “a historic decision on the destruction of Syria’s chemical weapons”.
UK Foreign Secretary William Hague: “It is a ground-breaking resolution”
In a statement after a late-night meeting in The Hague, the watchdog said its executive council “agreed on an accelerated programme for achieving the complete elimination of Syria’s chemical weapons by mid-2014. The decision requires inspections in Syria to commence from 1 October 2013”.
“The decision also calls for ambitious milestones for destruction which will be set by the (executive) council by 15 November.”
OPCW Director General Ahmet Uzumcu said the move “sends an unmistakable message that the international community is coming together to work for peace in Syria”.
These are unchartered waters for the OPCW, a small organisation that has never undertaken a job of this size or complexity, says the BBC’s world affairs correspondent Paul Adams.
It will need a lot of help and is expected to ask for urgent funding and additional personnel, he adds.
The UK is to contribute $3m (£1.85m) to the OPCW’s Syria fund, Foreign Secretary William Hague announced on Friday.
The OPCW document now forms part of the UN resolution which sets out to govern the whole process.
Meanwhile. violence continued in Syria. Activists said a car bomb killed at least 20 people near a mosque in Rankus, a town north of Damascus, just after Friday prayers.
Earlier, the UN said its team of inspectors currently in Syria are investigating three chemical weapons attacks alleged to have happened after the 21 August attack in Damascus that left hundreds dead and sparked a threat of US military action.
The three attacks are among seven alleged incidents the UN said its team were investigating.
The UN said its team, led by Ake Sellstrom, arrived in Syria for its second visit on 25 September and hopes to finish its work by Monday.